This was a double-blind, randomized, parallel and active-controlled clinical study initiated to evaluate the anti-hypertensive effect as well as the tolerability of Olive leaf extract in comparison to Captopril in patients with stage-1 hypertension (high blood pressure) . Additionally, this study also looked at the hypolipidemic effects of Olive leaf extract in such patients.
A clear reduction of triglyceride level was observed in Olive group, but not in Captopril group. In conclusion, Olive (Olea europaea) leaf extract, at the dosage regimen of 500 milligrams twice daily, was similarly effective in lowering systolic and diastolic blood pressures in subjects with stage-1 hypertension as Captopril, given at its effective dose of 12.5-25 mg twice daily.
Oleuropein doesn’t only occurs in the Olea genus, but also occurs in many other genera belonging to the Oleaceae family and has been previously described in Fraxinus excelsior, F. angustifolia, F. chinensis, Syringa josikaea, S. vulgaris, Philyrea latifolia, Ligustrum ovalifolium, L. vulgare, and many others.
Oleuropein is very abundant in the early stages: in young fruits, it can reach 14% of dry matter. Although lower, its level is still very important at harvest for green picked cultivars.
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